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姜启晓 副教授

2019年04月29日 10:56  点击:[]

  姜启晓,男,1983年11月生,山东青岛人。2007年本科毕业于老版新葡萄8883医学院,临床医学学士学位。2013年博士毕业于East Carolina University, Brody School of Medicine,获Ph.D. in Pharmacology & Toxicology学位,现为老版新葡萄8883官网下载副教授。



  主要从事毒理学的科研与教学工作,现为Society of Toxicology正式会员,中国毒理学会会员,中国环境诱变剂学会致突变专业委员会青年委员会委员,山东预防医学会卫生毒理分会第五届委员会委员,主持国家自然科学基金一项,参与一项,主持山东省自然科学基金一项。以通讯及第一作者共发表SCI论文20篇。



一、主要研究方向


1. 可吸入污染物的发育毒性,心肺毒性作用评价及机制研究


2. 全氟化合物及其替代品的发育心血管毒性作用评价及作用机制研究



二、代表性科研成果


代表性论文


1: Jiang Q, Xu X, DeWitt JC, Zheng Y. Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities. J Vis Exp. 2021 Mar 21;(169). doi: 10.3791/62189. PMID: 33818575.


2: Jiang Q, Zhang C, Chen S, Shi L, Li DC, Lv N, Cui L, Chen Y, Zheng Y. Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling. Front Pharmacol. 2020 Jun 5;11:841. doi: 10.3389/fphar.2020.00841. PMID: 32581800; PMCID: PMC7289969.


3: Jiang Q, Xu X, Zhang C, Luo J, Lv N, Shi L, Ji A, Gao M, Chen F, Cui L, Zheng Y. In ovo very early-in-life exposure to diesel exhaust induced cardiopulmonary toxicity in a hatchling chick model. Environ Pollut. 2020 Sep;264:114718. doi: 10.1016/j.envpol.2020.114718. Epub 2020 May 3. PMID: 32388309.


4: Yuan J, Jiang Q, Song L, Liu Y, Li M, Lin Q, Li Y, Su K, Ma Z, Wang Y, Liu D, Dong J. L-Carnitine Is Involved in Hyperbaric Oxygen-Mediated Therapeutic Effects in High Fat Diet-Induced Lipid Metabolism Dysfunction. Molecules. 2020 Jan 1;25(1):176. doi: 10.3390/molecules25010176. PMID: 31906305; PMCID: PMC6982999.


5: Lv N, Yuan J, Ji A, Shi L, Gao M, Cui L, Jiang Q. Perfluorooctanoic acid- induced toxicities in chicken embryo primary cardiomyocytes: Roles of PPAR alpha and Wnt5a/Frizzled2. Toxicol Appl Pharmacol. 2019 Oct 15;381:114716. doi: 10.1016/j.taap.2019.114716. Epub 2019 Aug 21. PMID: 31445018.


6: Lv N, Zhao M, Han Y, Cui L, Zhong W, Wang C, Jiang Q. The roles of bone morphogenetic protein 2 in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection. Toxicol Appl Pharmacol. 2018 Aug 1;352:68-76. doi: 10.1016/j.taap.2018.05.028. Epub 2018 May 23. PMID: 29800642.


7: Zhao M, Jiang Q, Geng M, Zhu L, Xia Y, Khanal A, Wang C. The role of PPAR alpha in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection-Results of in ovo gene silencing. Environ Toxicol Pharmacol. 2017 Dec;56:136-144. doi: 10.1016/j.etap.2017.09.006. Epub 2017 Sep 14. PMID: 28934691.


8: Zhao M, Jiang Q, Wang W, Geng M, Wang M, Han Y, Wang C. The Roles of Reactive Oxygen Species and Nitric Oxide in Perfluorooctanoic Acid-Induced Developmental Cardiotoxicity and l-Carnitine Mediated Protection. Int J Mol Sci. 2017 Jun 8;18(6):1229. doi: 10.3390/ijms18061229. PMID: 28594376; PMCID: PMC5486052.


9: Jiang Q, Wang C, Xue C, Xue L, Wang M, Li C, Deng Z, Wang Q. Changes in the levels of l-carnitine, acetyl-l-carnitine and propionyl-l-carnitine are involved in perfluorooctanoic acid induced developmental cardiotoxicity in chicken embryo. Environ Toxicol Pharmacol. 2016 Dec;48:116-124. doi: 10.1016/j.etap.2016.10.017. Epub 2016 Oct 19. PMID: 27771504.


10: Jiang Q, Ma W, Wu J, Wingard CJ, DeWitt JC. Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes. Environ Toxicol. 2016 Nov;31(11):1580-1590. doi: 10.1002/tox.22162. Epub 2015 Jun 22. PMID: 26098785.


11: Jiang Q, Hao R, Wang W, Gao H, Wang C. SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid. Mol Cell Biochem. 2016 Sep;420(1-2):171-84. doi: 10.1007/s11010-016-2787-x. Epub 2016 Aug 11. PMID: 27514536.


12: Jiang Q, Han Y, Gao H, Tian R, Li P, Wang C. Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K. Eur J Pharmacol. 2016 Jun 15;781:69-75. doi: 10.1016/j.ejphar.2016.04.001. Epub 2016 Apr 13. PMID: 27085898.


13: Jiang Q, Wang D, Han Y, Han Z, Zhong W, Wang C. Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the antiatherosclerosis effect of oleanolic acid. Int J Biochem Cell Biol. 2015 Dec;69:142-52. doi: 10.1016/j.biocel.2015.10.023. Epub 2015 Oct 25. PMID: 26510581.


14: Jiang Q, Lust RM, DeWitt JC. Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved? J Toxicol Environ Health A. 2013;76(11):635-50. doi: 10.1080/15287394.2013.789415. PMID: 23941634.


15: Jiang Q, Lust RM, Strynar MJ, Dagnino S, DeWitt JC. Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings. Toxicology. 2012 Mar 11;293(1-3):97-106. doi: 10.1016/j.tox.2012.01.005. Epub 2012 Jan 18. PMID: 22273728.


学术专著

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances-Chapter 7,2015年由Springer旗下Humana出版社出版, ISBN:978-3-319-15517-3


三、主要科研项目

1. 山东省自然科学基金面上项目,ZR2020MH335,全氟辛酸及替代物发育暴露致成年心毒性表观机制研究,10万元,在研,主持


2. 国家自然科学基金面上项目,81872591,基于mtDNA甲基化的大气颗粒物致心脏毒性机制及早期效应标志物探索,2019/01-2023/12,57万元,在研,参与


3. 国家自然科学基金青年项目,81502835 , 全氟辛酸(PFOA)诱导发育心脏毒性机制研究,2016/01-2018/12,18万元,结题,主持


四、获奖及荣誉称号

第四届全国大学生基础医学创新论坛暨实验设计大赛二等奖(指导教师)


首届全国MBBS项目青年教师英文讲课大赛优秀奖


老版新葡萄8883医学部第五届中青年教师英文授课大赛一等奖


老版新葡萄8883医学部第一届“课程思政”示范课教学大赛三等奖


联系方式

E-mail:jiangq08@126.com, jiangq@qdu.edu.cn


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