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唐敬龙 教授

2018年01月28日 21:47  点击:[]

     

  唐敬龙,教授,博士生导师,老版新葡萄8883官网下载院长助理。本科毕业于吉林大学,博士毕业于国家纳米科学中心/北京大学,中科院纳米生物效应与安全性重点实验室与北京大学前沿交叉学科研究院联合培养项目,获得博士学位。

  主要从事职业与环境卫生的教学科研工作,建立了在体-离体生物感受器模型(Ex vivo biosensor assay)评估吸入纳米/超细颗粒等环境污染物的健康效应与毒作用机制。主持国家自然科学基金面上项目和重点项目子课题各1项,并作为科研骨干参与“国家重点基础研究发展计划”项目,参与编写基金委“十四五预防医学学科发展报告”。在环境与职业场所暴露纳米颗粒物的健康效应与安全性评价领域取得了一定的成果,相关研究被国际知名杂志Advance Materials, ACS Nano, Biomaterials, Journal of Hazardous Materials, Particle & Fibre Toxicology, Environment International, Nanoscale, Environmental Pollution, Nanotoxicology, Toxicology Letters等收录,授权发明专利5项,指导研究生获山东省研究生优秀成果奖2项。

一、 主要研究方向

吸入毒理学,包括:

1. 吸入纳米颗粒或超细颗粒对呼吸系统的损伤及引起肺外效应的毒性机制研究

2. 吸入聚六亚甲基胍等消毒剂气溶胶引起肺纤维化的生物标志物识别与毒作用通路筛选

3. 利用纳米技术等手段对吸入毒物的有害健康结局进行调控和干预

二、代表性科研成果

1)学术论文

2022年

31. Yanting Li#, Teng Shi#, Xin Li, Huimin Sun, Xiaowen Xia, Xiaoya Ji, Jianzhong Zhang, Meike Liu, Yongfeng Lin, Rong Zhang, Yuxin Zheng*, Jinglong Tang*. Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement. Environment International. 2022, 164:107257. (共同通讯作者,IF=9.621)

30. Jianzhong Zhang#, Xin Li#, Wenting Cheng, Yanting Li, Teng Shi, Yingying Jiang, Tao Wang, Hongmei Wang, Dunqiang Ren, Rong Zhang, Yuxin Zheng, Jinglong Tang*. Chronic carbon black nanoparticles exposure increases lung cancer risk by affecting the cell cycle via circulatory inflammation. Environmental Pollution. 2022, 305:119293. (通讯作者,IF=8.071)

29. Wenting Cheng#, Huanhuan Pang#, Matthew J. Campen, Jianzhong Zhang, Yanting Li, Jinling Gao, Dunqiang Ren, Xiaoya Ji, Nathaniel Rothman, Qing Lan, Yuxin Zheng, Shuguang Leng*, Zeping Hu*, Jinglong Tang*. Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust. Particle and Fibre Toxicology. 2022, 19:20. (共同通讯作者,IF=9.400)

28. Xiaoya Ji#, Rui Liu#, Jiajun Guo, Yanting Li, Wenting Cheng, Yaxian Pang, Yuxin Zheng, Rong Zhang*, Jinglong Tang*. Olfactory bulb microglia activation mediated neuronal death in real-ambient particulate matter exposure mice with depression-like behaviors. Science of The Total Environment. 2022, 821:153456. (共同通讯作者,IF=7.963)

27. Huimin Sun, Yanting Li, Jianzhong Zhang, Teng Shi, Xin Li, Xue Cao, Tao Wang, Nan Kong, Yaxian Pang, Tsendmaa Bold, Yuxin Zheng, Rong Zhang*, Jinglong Tang*. Platelet mitochondrial DNA methylation as epigenetic biomarker of short-term air pollution exposure in healthy subjects. Frontiers in Molecular Biosciences. 2022,8: 803488. (共同通讯作者,IF=5.639)

26. 程文婷, 郑玉新, 唐敬龙*. 在体-离体生物感受细胞模型在毒理学评价中的应用进展. 中华预防医学杂志, 2022, 56(1) : 25-28.

2021年

25.Xin Li, Jianzhong Zhang, Chao Du, Yingying Jiang, Wanjun Zhang, Shuo Wang, Xiaoxiao Zhu, Jinling Gao, Xinru Zhang, Dunqiang Ren, Yuxin Zheng, Jinglong Tang*. Polyhexamethylene guanidine aerosol triggers pulmonary fibrosis concomitant with elevated surface tension via inhibiting pulmonary surfactant. Journal of Hazardous Materials. 2021, 420(15):126642.(通讯作者,IF=10.588)

24. Wanjun Zhang#, Jinling Gao#, Lin Lu, Tsendmaa Bold, Xin Li, Shuo Wang, Zhishang Chang, Jing Chen, Xiao Kong, Yuxin Zheng, Mingliang Zhang*, Jinglong Tang*. Intracellular GSH/GST antioxidants system change as an earlier biomarker for toxicity evaluation of iron oxide nanoparticles. NanoImpact. 2021, 23:100338. (共同通讯作者,IF=5.478)

23. Yanan Li#, Jing Chen#, Shuhua Bu, Shuo Wang, Xue Geng, Ge Guan, Qianwen Zhao, Lin Ao, Weidong Qu, Yuxin Zheng, Yuan Jin*, Jinglong Tang*. Blood lead levels and their associated risk factors in Chinese adults from 1980 to 2018. Ecotoxicology and Environmental Safety. 2021, 218:112294. (共同通讯作者,IF=6.291)

22. Xue Geng, Xiaohui Liu, Xin Li, Tao Wang, Jianzhong Zhang, Yuxin Zheng, Jian Chen*, Jinglong Tang*. Impact of ambient particulate matter on respiratory-related school absence: a case-crossover study in China. Air Quality, Atmosphere & Health. 2021, 14:1203-1210. (共同通讯作者,IF=3.763)

21. Shuo Wang#, Yuan Jin#, Jing Chen, Lin Lu, Yanan Li, Qianwen Zhao, Shuhua Bu, Xue Geng, Ge Guan, Weidong Qu, Yuxin Zheng, Jinglong Tang*. Blood lead levels of Chinese children from 1991 to 2020: Based on Monte Carlo simulation. Environmental Pollution. 2021, 278:116823. (通讯作者,IF=8.071)

20. Jinling Gao#, Huige Zhou#, Yanjie Zhao, Lin Lu, Jianzhong Zhang, Wenting Cheng, Xuxia Song, Yuxin Zheng, Chunying Chen*, Jinglong Tang*. Time-course effect of ultrasmall superparamagnetic iron oxide nanoparticles on intracellular iron metabolism and ferroptosis activation. Nanotoxicology. 2021, 15(3):366-379. (共同通讯作者,IF=5.913)

19. 刘蕊,季晓亚,唐敬龙*. 纳米颗粒物对嗅球影响及其机制的研究进展. 环境与职业医学杂志. 2021, 38(4):419-424.

2020年

18. Xiaoxiao Zhu, Xiao Kong, Sai Ma, Rui Liu, Xin Li, Shaobo Gao, Dunqiang Ren, Yuxin Zheng*, Jinglong Tang*. TGFβ/Smad mediated the polyhexamethylene guanide areosol-induced irreversible pulmonary fibrosis in subchronic inhalation exposure. Inhalation Toxicology. 2020,32(11-12):419-430. (共同通讯作者,IF=1.895)

17. Jinglong Tang, Wenting Cheng, Jinling Gao, Yanting Li, Ruyong Yao, Nathaniel Rothman, Qing Lan, Matthew J. Campen, Yuxin Zheng, Shuguang Leng. Occupational exposure to carbon black nanoparticles increases inflammatory vascular disease risk: an implication of an ex vivo biosensor assay. Particle and Fibre Toxicology. 2020,17:47 (第一作者,IF=7.546)

16. Jinglong Tang#, Ruirui Zhang#, Mengyu Guo, Huige Zhou, Yuliang Zhao, Ying Liu, Yan Wu*, Chunying Chen*. Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy. Journal of Controlled Release 2020, 320:293-303. (共同第一作者,IF=7.727)

15. Wenting Cheng#, Yuansheng Liu#, Jinglong Tang#, Huawei Duan, Xiaoran Wei, Xiao Zhang, Shanfa Yu, Matthew Campen, Wei Han, Nathaniel Rothman, Steven A Belinsky, Qing Lan, Yuxin Zheng*, Shuguang Leng*. Carbon content in airway macrophages and genomic instability in Chinese carbon black packers. Archives of Toxicology 2020, 94(3):761-771. (共同第一作者,IF=5.059)

14. 唐敬龙,祝肖肖,郑玉新. 吸入胍类消毒剂致肺损伤的毒性特征及机制研究进展. 中华预防医学杂志,2020,54(2):209-212.

13. 祝肖肖,孟涛,冷曙光,郑玉新,唐敬龙*. 重复吸入阳离子胍类消毒剂引起小鼠肺的纤维化改变研究. 中华预防医学杂志, 2020, 54(2):198-202.

2019年

12. Guanglei Wang, Xiaomei Zheng, Huawei Duan, Yufei Dai, Yong Niu, Jinling Gao, Zhishang Chang, Xuxia Song, Shuguang Leng, Jinglong Tang*, Yuxin Zheng*. High-content analysis of particulate matters-induced oxidative stress and organelle dysfunction in vitro. Toxicology in Vitro 2019, 59:263-274. (共同通讯作者,IF=3.067)

11. Jinglong Tang, Mengyu Guo, Peng Wang, Jing Liu, Yating Xiao, Wenting Cheng, Jinling Gao, Wenquan Hu, Qing Robert Miao*. Gd-Metallofullerenol nanoparticles cause intracellular accumulation of PDGFR-α and morphology alteration of fibroblasts. Nanoscale 2019, 11(11):47473-4750. (第一作者,IF=6.970)

2018年

10. Guanglei Wang, Xiaomei Zheng, Jinglong Tang*, Yong Niu, Yufei Dai, Huawei Duan, Yuxin Zheng*. LIN28B/let-7 axis mediates pulmonary inflammatory response induced by diesel exhaust particle exposure in mice. Toxicology Letters 2018, 299(15):1-10. (共同通讯作者,IF=3.166)

9. Jinglong Tang#, Ruirui Zhang#, Mengyu Guo, Leihou Shao, Ying Liu, Yuliang Zhao, Yan Wu*, Chunying Chen*. Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin. Biomaterials 2018, 167:205-215. (共同第一作者,IF=8.806)

8. 唐敬龙,郑玉新. WHO人造纳米材料职业防护指南解读. 中华预防医学杂志,2018,52(8):782-784.

2014-2017年

7. Jinglong Tang#, Huige Zhou#, Jiaming Liu, Jing Liu, Wanqi Li, Yuqing Wang, Fan Hu, Qing Huo, Jiayang Li, Ying Liu, Chunying Chen*. Dual-Mode Imaging-Guided Synergistic Chemo- and Magnetohyperthermia Therapy in a Versatile Nanoplatform to Eliminate Cancer Stem Cells. ACS Applied Materials & Interfaces 2017, 9(28): 23497-23507. (共同第一作者,IF=7.504)

6. Jinglong Tang, Zhiyun Chen, Baoyun Sun, Jinquan Dong, Jing Liu, Huige Zhou, Liming Wang, Ru Bai, Qing Miao, Yuliang Zhao, Chunying Chen, Ying Liu*. Polyhydroxylated Fullerenols Regulate Macrophage for Cancer Adoptive Immunotherapy and Greatly Inhibit the Tumor Metastasis. Nanomedicine-Nanotechnology Biology and Medicine 2016, 12(4): 945-954. (第一作者,IF=5.671)

5. Jinglong Tang#, Xiumei Jiang#, Liming Wang, Hui Zhang, Zhijian Hu, Ying Liu, Xiaochun Wu*, Chunying Chen*. Au@Pt Nanostructures: A Novel Photothermal Conversion Agent for Cancer Therapy. Nanoscale 2014, 6(7): 3670-3678. (共同第一作者,IF=6.793)

4. Xin Nie#, Jinglong Tang#, Ying Liu, Rong Cai, Qing Miao, Yuliang Zhao, Chunying Chen*. Fullerenol Inhibits the Cross-talk between Bone Marrow-Derived Mesenchymal Stem Cells and Tumor Cells by Regulating MAPK Signaling. Nanomedicine: nanotechnology, biology, and medicine 2017, 13(6): 1879-1890. (共同第一作者,IF=5.720)

3. Huige Zhou#, Jinglong Tang#, Jiayang Li, Wanqi Li, Ying Liu, Chunying Chen*. In Vivo Aggregation-Induced Transition between T-1 and T-2 Relaxations of Magnetic Ultra-Small Iron Oxide Nanoparticles in Tumor Microenvironment. Nanoscale 2017, 9(9): 3040-3050. (共同第一作者,IF=7.367)

2. Yang Li#, Jinglong Tang#, Dong-Xu Pan, Ling-Dong Sun*, Chunying Chen*, Ying Liu, Ye-Fu Wang, Shuo Shi, Chun-Hua Yan*. A Versatile Imaging and Therapeutic Platform Based on Dual- Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging. Advanced Materials 2015, 27(27): 4075-4080.Band Luminescent Lanthanide Nanoparticles toward Tumor Metastasis Inhibition. ACS Nano 2016, 10(2): 2766-2773. (共同第一作者,IF=13.334)

1. Yantao Li#, Jinglong Tang#, Liangcan He, Yong Liu, Yaling Liu, Chunying Chen*, Zhiyong Tang*. Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging. Advanced Materials 2015, 27(27): 4075-4080.(共同第一作者,IF=17.493)

2) 发明专利

7. 一种检测苯并[a]芘暴露的表观遗传学标志物及应用,2022100465893,第一发明人。

6. 一种铁死亡激活剂及其制备和应用,202010569893.7,第一发明人。

5. 一种肺纤维化哺乳动物模型的构建及应用,201911065110.5(已授权),第一发明人。

4.. 一种体外呼吸暴露模型构建方法和应用,201811364289.X(已授权),第一发明人。

3. 一种负载有盐酸阿霉素的纳米粒子及其制备方法和用途,201810142761.9(已授权),第二发明人。

2. 一 种磁性纳 米 药 物 复 合 体 及 其 制 备 方 法 和 应 用 ,201610708677.X(已授权),第二发明人。

1. 一种肿瘤靶向的 T1-T2 双核磁共振成像造影剂及其制备方法和应用,201510158246.6(已授权),第二发明人。

三、主要科研项目

1. 国家自然科学基金重大研究计划重点项目,92043202,肺造血免疫介导的室内细颗粒物致心血管系统危害特征的研究,2021/01-2022/12,300万元,在研,子课题负责人(80万)

2. 国家自然科学基金面上项目,81872651,铁凋亡途径在纳米氧化铁颗粒诱导的毒性中的作用研究,2019/01-2022/12,57万元,在研,主持

3. 科技部重点研发计划,SQ2017YFC160084-2,基于人群队列的食品污染物生物标志物研究与应用,2018/01-2021/12,369万元,结题,参与

四、主要学术兼职

中国毒理学会纳米毒理学专业委员会委员

中国环境诱变剂学会生物标志物专业委员会委员

中国毒理学会毒理学替代法与转化毒理学专业委员会青年委员

中国毒理学会呼吸毒理专业委员会青年委员

全国公共卫生与预防医学名词编写委员会环境卫生学名词编写分委会委员

山东省预防医学会卫生毒理分会委员

山东省健康促进与教育学会身心健康促进专业委员会委员

《职业卫生与应急救援》杂志编委

《精准医学杂志》青年编委



个人学术主页:

https://www.researchgate.net/profile/Jinglong-Tang

https://publons.com/researcher/1378729/jinglong-tang/


联系方式:

青岛市宁德路2号老版新葡萄8883浩园医学综合楼A座 老版新葡萄8883官网劳动卫生与环境卫生学系

E-mail:tangjinglong(AT)qdu.edu.cn   Tel:(0532)85950658


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